Subject to county cup commitments, the 16 second round ties are set to be played in the week commencing November 27. Clubs who make it through the early rounds will collect £250 for reaching the quarter-finals and £500 for making the semi-finals. Like 2017 winners Bamber Bridge, next April's winners will collect £2,000 with the losing finalists banking £1000. If the scores are level in the upcoming ties after 90 minutes, penalties will decide the results.

Atherton Collieries v Bamber Bridge
Buxton or Coalville Town v Stamford
Cleethorpes Town v Ossett Albion or Tadcaster Albion
Droylsden or Nantwich Town v Witton Albion
Gresley v Basford United
Hednesford Town v Newcastle Town
Matlock Town v Grantham Town
Mickleover Sports v Bedworth United
Mossley v Altrincham
Ramsbottom United or Stalybridge Celtic v Hyde United
Romulus v Kidsgrove Athletic
Scarbrough Athletic v Goole or Ossett Town
South Shields v Stocksbridge Park Steels
Stafford Rangers v Stourbridge or Alvechurch
Warington Town v Lancaster City
Workington v Marine